Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin
نویسندگان
چکیده
منابع مشابه
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
Perforin is a secreted protein synthesized by activated cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. It is a key component of the lytic machinery of these cells, being able to insert into the plasma membrane of targeted cells, forming a pore which leads to their destruction. Here we analyse the synthesis, processing and intracellular transport of perforin in the NK cell line YT....
متن کاملResponse : Mechanisms of perforin resistance : the differentiation between perforin binding and perforin - mediated lysis remains difficult
tomized patients. For example, pretransplantation disease duration was somewhat longer (albeit not significantly so) in splenectomized patients, and although not the case in the present study, disease duration has been found to be inversely correlated with posttransplantation outcome for other indications. In addition, splenectomized patients tended to be older and more often received a transpl...
متن کاملPerforin lytic activity is controlled by calreticulin.
The components within cytotoxic lymphocyte granules are responsible for a significant fraction of T and NK cell-mediated death. Perforin is stored in these granules together with calreticulin. Calreticulin has long been recognized as a chaperone protein of the endoplasmic reticulum (ER) and is the only resident ER protein to be found in the cytotoxic granules. Here we implicate a role for calre...
متن کامل[The role of perforin mediated cell cytotoxicity in psoriasis].
Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferation and incomplete differentiation of epidermal keratinocytes as well as by inflammatory infiltrate of T-lymphocytes in dermis and epidermis. Psoriasis is nowadays also recognized as a T cell mediated disease resulting from aberrant activation of both innate and adaptive immunity. The main effector cells in ...
متن کاملCD8-mediated protection against Ebola virus infection is perforin dependent.
CD8 T cells have been shown to play an important role in the clearance and protection against fatal Ebola virus infection. In this study, we examined the mechanisms by which CD8 T cells mediate this protection. Our data demonstrate that all normal mice infected s.c. with a mouse-adapted Ebola virus survived the infection, as did 100% of mice deficient in Fas and 90% of those deficient in IFN-ga...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2018
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-018-0057-z